"Bone has a remarkable endogenous regenerative capacity that enables scarless healing and restoration of its prior mechanical function, even under challenging conditions such as advanced age and metabolic or immunological degenerative diseases. However — despite much progress — a high number of bone injuries still heal with unsatisfactory outcomes. The mechanisms leading to impaired healing are heterogeneous, and involve exuberant and non-resolving immune reactions or overstrained mechanical conditions that affect the delicate regulation of the early initiation of scar-free healing. Every healing process begins phylogenetically with an inflammatory reaction, but its spatial and temporal intensity must be tightly controlled. Dysregulation of this inflammatory cascade directly affects the subsequent healing phases and hinders the healing progression."
01.01.2023 To 31.12.2023
CRC 1444 Wolff Lecture Series 2023
For the CRC 1444 community
As part of the Julius Wolff Lecture, the scientists of the CRC network report on the latest results and developments within the framework of the Collaborative Research Centre 1444.
06.12.2023 To 08.12.2023
The Regenerative Games: Uniting the worlds of tissue regeneration
BSRT Symposium 2023
Sports Games have been a symbol of unity for over a century, bringing people together through their shared passion for sports. This year marks the inaugural edition of The Regenerative Games of Tissue Regeneration, which seeks to unite individuals in their pursuit of discovering the keys to regenerative medicine.
Network for research into bone healing in biologically and mechanically challenging healing situations
Using bone healing as an example, our research aims to unravel the fundamental mechanisms that make the difference between success and failure in musculoskeletal tissue regeneration. In 2014, the DFG Research Group 2165 Regeneration in Aged was founded. In 2021, this became the DFG Collaborative Research Centre 1444.