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DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

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Subproject 3 - Principal Investgators

Prof. Dr. Ansgar Petersen

CRC 1444 Subprojects 3 & 10 | RU 2165 Subproject 4

Ansgar Petersen
Prof. Dr. Petra Knaus

CRC 1444 Representative of partner university & Education of early career scientists, Subprojects 3 & 4 | RU 2165 Subprojects 3

ECM coding and reading: alterations of ECM properties under compromised conditions and consequences for regeneration

In order to understand alterations of extracellular matrix properties under compromised conditions and consequences for regeneration, Petersen and Knaus will investigate extracellular matrix coding and reading in their project. They will elucidate how information encoded in the extracellular matrix influences cell function in the context of bone regeneration. Specifically, they aim at deciphering alterations of the here-defined "matrix code" under compromised conditions related to aging (altered immune status, bone marrow adiposity) in vitro. They hypothesise that precursor cells, if recruited from a compromised bone marrow niche to a bone defect would deposit a compromised extracellular matrix that is modulated additionally by the immune system. The resulting compromised extracellular matrix in turn alters progenitor cell function and thereby entails an impaired healing pathway.

Most important results

Growth factor - receptor affinities

Inflammatory Response | Force Transmission & Sensing

Receptor complexes of the TGFβ/BMP superfamily can be visualised by N-terminal halo and SNAP labelled receptors in combination with fluorescently labelled growth factors.

Jatzlau et al. Commun Biol 2023 | In collaboration with subproject P04

Substrate stiffness

Inflammatory Response | Force Transmission & Sensing

Changes in substrate stiffness alone are not sufficient for the differentiation of endothelial cells from iPS cells.


Inflammatory Response | Force Transmission & Sensing

2D and 3D Traction Force Microscopy (TFM) were developed to study mechanical forces during angiogenesis of iPS-derived endothelial cells.

In collaboration with subproject P10


Mounir Benamar (Doctoral Researcher)

Correlative approach to study endothelial junction architecture and sprouting angiogenesis in iPSC-derived endothelial cells for different disease models

Wiktor Burdzinski (Doctoral Researcher)

Resolving the Activin A receptor complex and its endothelial function in Fibrodysplasia Ossificans Progressiva (FOP)

Rebecca Günther (Doctoral Researcher)

Extracellular matrix coding and reading: Alterations under compromised conditions and consequences for cell behavior in tissue regeneration

Nurcan Haştar (Doctoral Researcher)

Deciphering the brain integrity and modulation of endothelial cell junctions under the control of BMP

Jerome Jatzlau (Postdoc)

Shear-stress dependent modulation of BMP-induced transcription






Founded by the DFG (Project Number: 427826188)
Funding Period 2021-2024