DFG Collaborative Research Centre 1444
This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.
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Effects of implant-derived metal debris on bone formation and resorption
Geißler and Perka will investigate the effects of implant-derived metal exposure on bone remodelling and bone marrow composition. Implant-derived metal exposure represents a chronic pro-inflammatory model and disturbs the complex mutual regulation between multipotent lymphoid progenitor, adult immune and mesenchymal stromal cells. Bone homeostasis and regeneration are affected and long-lasting negative effects such as implant loosening and higher re-revision rates are observed in affected patients. Using patient material, the effect of metallic exposure on the pro-inflammatory environment in bone homeostasis will be characterised. A microfluidic 3D bone-on-a-chip system will be utilised to understand the effects of metal exposure on bone formation and how the individual immune profiles drives mechanisms and consequences of inflammation-associated bone loss.