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DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

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Subproject 5 - Principal Investgators

Dr. Sven Geißler

CRC 1444 Subprojects 5 & 16 | RU 2165 Subproject 2

Prof. Dr. Carsten Perka

CRC 1444 Subproject 5 & Central Service Project

Effects of implant-derived metal debris on bone formation and resorption

Geißler and Perka will investigate the effects of implant-derived metal exposure on bone remodelling and bone marrow composition. Implant-derived metal exposure represents a chronic pro-inflammatory model and disturbs the complex mutual regulation between multipotent lymphoid progenitor, adult immune and mesenchymal stromal cells. Bone homeostasis and regeneration are affected and long-lasting negative effects such as implant loosening and higher re-revision rates are observed in affected patients. Using patient material, the effect of metallic exposure on the pro-inflammatory environment in bone homeostasis will be characterised. A microfluidic 3D bone-on-a-chip system will be utilised to understand the effects of metal exposure on bone formation and how the individual immune profiles drives mechanisms and consequences of inflammation-associated bone loss.





Founded by the DFG (Project Number: 427826188)
Funding Period 2021-2024