DFG Collaborative Research Centre 1444
This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.
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In vivo forces and musculoskeletal loading conditions in human fracture healing
In vivo forces and musculoskeletal loading conditions are frequently unknown in human fracture healing settings. Using patient anatomy, fracture geometry and fracture fixation from the BioBone cohort, Zachow and Trepczynski aim at unravelling the mechanical conditions at the site of a fracture. They focus on a detailed quantitative analysis of the mechanical boundary conditions in elderly or otherwise compromised patients. Their predictions will be verified by measuring the relative interfragmentary motion components (compression and shear) in vivo. They want to assess the occurring ranges of fracture motion during healing progression to be able to stratify the initial mechanical conditions derived from the fracture fixation treatment.
Clinical fracture healing
Inflammatory Response | Force Transmission & Sensing
Evaluation and scoring of x-ray images during follow-up reveal different patterns and speed of healing within and between bones, which are associated to differences in loading and generally different biomechanical conditions.
In collaboration with the central service project C01
Prospective laboratory study
Inflammatory Response | Force Transmission & Sensing
Establishment of laboratory testing standards and a measurement protocol for a world-wide unique dual-plane video-fluoroscope enables direct measurement of internal kinematics (relative bone fragment motion) under physiological loads in fracture patients in vivo.
Publications
- Authors:Augat, P.; Hast, M.W.; Schemitsch, G.; Heyland, M.; Trepczynski, A.; Borgiani, E.; Russow, G.; Märdian, S.; Duda, G.; Hollensteiler, M.; Bottlang, M.; Schemitsch, E.H.
Journal:OTA International Year:2021;
Title:Biomechanical models: Key considerations in study design - Authors:Märdian, S.; Tsitsilonis, S.; Ahmad, S.; Culemann, U.; Duda, G.; Heyland, M.; Stöckle U
Journal:Chirurg Year:2021; Volume:92Issue:(10):Pages:863-872.
Title:Was macht eine gute Osteosynthese aus? - Authors:Moewis, P.; Kaiser, R.; Trepczynski, A.; von Tycowicz, C.; Krahl, L.; Ilg, A.; Holz, J.; Duda, G. N.
Journal:Knee Surg Sports Traumatol Arthrosc Year:2023; Volume:31Issue:(4):Pages:1247-1266.
Title:Patient-specific resurfacing implant knee surgery in subjects with early osteoarthritis results in medial pivot and lateral femoral rollback during flexion: a retrospective pilot study - Authors:Biehl, M.; Damm, P.; Trepczynski, A.; Preiss, S.; Salzmann, G. M.
Journal:J Exp Orthop Year:2021; Volume:8Issue:(1):Pages:39.
Title:Towards planning of osteotomy around the knee with quantitative inclusion of the adduction moment: a biomechanical approach - Authors:Hosseini Nasab, S. H.; Smith, C. R.; Maas, A.; Vollenweider, A.; Dymke, J.; Schutz, P.; Damm, P.; Trepczynski, A.; Taylor, W. R.
Journal:Front Bioeng Biotechnol Year:2022; Volume:10:Pages:808027.
Title:Uncertainty in Muscle-Tendon Parameters can Greatly Influence the Accuracy of Knee Contact Force Estimates of Musculoskeletal Models - Authors:Winkler, T.; Bell, L.; Bender, A.; Trepczynski, A.; Duda, G. N.; Baur, A. J. D.; Damm, P.
Journal:Front Bioeng Biotechnol Year:2023; Volume:11:Pages:1075357.
Title:Periarticular muscle status affects in vivo tibio-femoral joint loads after total knee arthroplasty - Authors:Kneifel, P.; Moewis, P.; Damm, P.; Schutz, P.; Dymke, J.; Taylor, W. R.; Duda, G. N.; Trepczynski, A.
Journal:J Biomech Year:2023; Volume:151:Pages:111549.
Title:Patellar tendon elastic properties derived from in vivo loading and kinematics - Authors:Dreyer, M. J.; Trepczynski, A.; Hosseini Nasab, S. H.; Kutzner, I.; Schutz, P.; Weisse, B.; Dymke, J.; Postolka, B.; Moewis, P.; Bergmann, G.; Duda, G. N.; Taylor, W. R.; Damm, P.; Smith, C. R.
Journal:J Biomech Year:2022; Volume:141:Pages:111171.
Title:European Society of Biomechanics S.M. Perren Award 2022: Standardized tibio-femoral implant loads and kinematics - Authors:Trepczynski, A.; Moewis, P.; Damm, P.; Schutz, P.; Dymke, J.; Hommel, H.; Taylor, W. R.; Duda, G. N.
Journal:Front Bioeng Biotechnol Year:2021; Volume:9:Pages:754715.
Title:Dynamic Knee Joint Line Orientation Is Not Predictive of Tibio-Femoral Load Distribution During Walking
