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DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

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Subproject 6 - Principal Investgators

Dr. Stefan Zachow

CRC 1444 Subproject 6

Dr. Adam Trepczynski

CRC 1444 Subproject 6

In vivo forces and musculoskeletal loading conditions in human fracture healing

In vivo forces and musculoskeletal loading conditions are frequently unknown in human fracture healing settings. Using patient anatomy, fracture geometry and fracture fixation from the BioBone cohort, Zachow and Trepczynski aim at unravelling the mechanical conditions at the site of a fracture. They focus on a detailed quantitative analysis of the mechanical boundary conditions in elderly or otherwise compromised patients. Their predictions will be verified by measuring the relative interfragmentary motion components (compression and shear) in vivo. They want to assess the occurring ranges of fracture motion during healing progression to be able to stratify the initial mechanical conditions derived from the fracture fixation treatment.

Most important results

Clinical fracture healing

Inflammatory Response | Force Transmission & Sensing

Evaluation and scoring of x-ray images during follow-up reveal different patterns and speed of healing within and between bones, which are associated to differences in loading and generally different biomechanical conditions.

In collaboration with the central service project C01

Prospective laboratory study

Inflammatory Response | Force Transmission & Sensing

Establishment of laboratory testing standards and a measurement protocol for a world-wide unique dual-plane video-fluoroscope enables direct measurement of internal kinematics (relative bone fragment motion) under physiological loads in fracture patients in vivo.

Click on image for video

Interfragmentary motion

Inflammatory Response | Force Transmission & Sensing

In vitro testing under physiological loads demonstrates the capability to capture interfragmentary motions

Internal bone loading

Inflammatory Response | Force Transmission & Sensing

Combined measurements of gait, in vivo loading and internal kinematics, augmented by musculoskeletal modelling provided access to internal loading along the bone shaft of femur and tibia.


Dominik Deppe (Clinician Scientist)

Musculoskeletal imaging in fracture healing

Dr. Ing. Mark Heyland (Postdoc)

Fracture fixation and mechanical boundary conditions in fracture healing

Marko Leskovar (Doctoral Researcher)

3D Assessment of multi-body dynamics using bi-planar video-fluoroscopy

Marie-Jacqueline Reisener (Clinician Scienitst bis 06/2022)

Musculoskeletal imaging in fracture healing






Founded by the DFG (Project Number: 427826188)
Funding Period 2021-2024