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DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

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Subproject 6 - Principal Investgators

Dr. Stefan Zachow

CRC 1444 Subproject 6

Dr. Adam Trepczynski

CRC 1444 Subproject 6

In vivo forces and musculoskeletal loading conditions in human fracture healing

In vivo forces and musculoskeletal loading conditions are frequently unknown in human fracture healing settings. Using patient anatomy, fracture geometry and fracture fixation from the BioBone cohort, Zachow and Trepczynski aim at unravelling the mechanical conditions at the site of a fracture. They focus on a detailed quantitative analysis of the mechanical boundary conditions in elderly or otherwise compromised patients. Their predictions will be verified by measuring the relative interfragmentary motion components (compression and shear) in vivo. They want to assess the occurring ranges of fracture motion during healing progression to be able to stratify the initial mechanical conditions derived from the fracture fixation treatment.

Founded by the DFG (Project Number: 427826188)