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DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

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Subproject 1 - Principal Investgators

PD Dr. Katharina Schmidt-Bleek

CRC 1444 Subprojects 1 & 12
RU 2165 Subprojects 5 & 6 (completed)

Katharina Schmidt-Bleek
Prof. Dr. Hans-Dieter Volk

CRC 1444 Subprojects 1 & 2
RU Subproject 5 (completed)

Understand and reshape the impact of an experienced adaptive immunity on fracture healing

Schmidt-Bleek and Volk aim to understand and reshape the impact of an experienced adaptive immunity on fracture healing. They will investigate the favourable and detrimental influence of specific immune cell subsets (effector CD8+ T cells, CD4+ T regulatory (Treg) cells, T helper 17 cells) and their cytokines and signalling cascades in an immune experienced, clinically relevant bone injury mouse model in order to understand their impact during bone regeneration. They aim to reshape the negative impact of an "experienced" pro-inflammatory adaptive immunity to enhance bone regeneration by local immunomodulation.

Most important results

Microbiome diversity

Inflammatory Response | Energy Supply & Consumption

Analysis of the gut microbiome showed substantial alterations post-surgery due to differences in the level of immunological experience.

Bucher et al. Exp. Mol. Med. 2022

Multifaceted roles of macrophages

Energy Supply & Consumption | Force Transmission & Sensing

Macrophages and their phenotype are essential for the revascularization steps in bone healing / biomechanics incfluence macrophage polarization.

Schlund et al Acta Biomater. 2021 | In collaboration with subproject P09 

Inflammatory cytokines

Inflammatory Response | Force Transmission & Sensing

Inflammatory cytokines direct ECM deposition in vitro.

In collaboration with subprojekt P03 

Founded by the DFG (Project Number: 427826188)