DFG Collaborative Research Centre 1444
This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.
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Subproject 1 - Principal Investgators
CRC 1444 Subprojects 1 & 12
RU 2165 Subprojects 5 & 6 (completed)
CRC 1444 Subprojects 1 & 2
RU Subproject 5 (completed)
Understand and reshape the impact of an experienced adaptive immunity on fracture healing
Schmidt-Bleek and Volk aim to understand and reshape the impact of an experienced adaptive immunity on fracture healing. They will investigate the favourable and detrimental influence of specific immune cell subsets (effector CD8+ T cells, CD4+ T regulatory (Treg) cells, T helper 17 cells) and their cytokines and signalling cascades in an immune experienced, clinically relevant bone injury mouse model in order to understand their impact during bone regeneration. They aim to reshape the negative impact of an "experienced" pro-inflammatory adaptive immunity to enhance bone regeneration by local immunomodulation.
Multifaceted roles of macrophages
Energy Supply & Consumption | Force Transmission & Sensing
Macrophages and their phenotype are essential for the revascularization steps in bone healing / biomechanics incfluence macrophage polarization.
Schlund et al Acta Biomater. 2021 | In collaboration with subproject P09
Inflammatory cytokines
Inflammatory Response | Force Transmission & Sensing
Inflammatory cytokines direct ECM deposition in vitro.
In collaboration with subprojekt P03
Founded by the DFG (Project Number: 427826188)