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Katharina Schmidt-Bleek

PD Dr. Katharina Schmidt-Bleek

CRC 1444 Deputy Scientific Coordinator & Implementation of 3R principles, Subprojects 1 & 12 | RU 2165 Subprojects 5 & 6

Charité - Universitätsmedizin Berlin
Julius Wolff Institut
Föhrer Str. 15
13353 Berlin

Campus / internal address:
Südstraße 2

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In her research, Dr. rer. nat Katharina Schmidt-Bleek aims to unravel the regeneration capacity of bone tissue. This research area allows her to combine her two university qualifications, molecular medicine and veterinary medicine, to study the organ system “bone” in vitro and in vivo. She is specifically interested in the interaction between the musculoskeletal and the immune system with a particular focus on the adaptive immune system.

The complex processes of bone healing, adaptation and homeostasis offer a multitude of fascinating research approaches, which address the currently unmet clinical needs in the field of bone healing. Especially the demographic changes with an increasingly aged population generates more need for knowledge in this clinical field. Particularly the emerging field of osteoimmunology offers promising therapeutic approaches in this respect. The need for basic research knowledge for the development of such therapeutic approaches is central to the research group of Katharina Schmidt-Bleek.

Additional information

Member of the Steering committee of the CRC 1444
Deputy Scientific Coordinator &
Implementation of 3R principles


Publications in the framework of the RU 2165 and the CRC 1444

Burkhardt et al. Front. Cell Dev. Biol. 2023 

Drzeniek et al. Biomaterials 2023

Duda et al. Nat. Rev. Rheumatol. 2023

Bucher et al. Exp. Mol. Med. 2022

Schlundt et al Acta Biomater. 2021

Schlundt et al Front. Immunol. 2019

Bucher et al Front. Immunol. 2019

Wendler et al Front. Immunol. 2019

Sbierski-Kind et al J. Vis. Exp. 2019

Sbierski-Kind et al Front. Immunol. 2018

El-Khassawna et al Front. Immunol. 2017

Sass et al J. Bone Miner. Res. 2017

Lei et al Front. Pharmacol. 2015


Patente im Rahmen der FOR 2165

EP3675909 - Immunmodulation for prevention of poor healing of musculoskeletal injuries in compromised patients

EP3631450 - CD8 T cell subsets as a biomarker for predicting non-fusion after spinal fusion surgery

EP3254697 - Means for treating delayed fracture healing

EP2810065 - CD8+ T-cell subsets as markers for prediction of delayed fracture healing

Vita PD Dr. Katharina Schmidt-Bleek

Professional Development

  • December 2019
  • Since 2016
    Head of the Research Facility “Advanced Animal Models”
  • Since 2012
    Research Group Leader “Biology of Bone Healing”
  • 2012
    Veterinarian for Laboratory Animal Science
  • Since 2010
    Prinzipal Investigator “Osteoimmunology”
  • Since 2006
    Veterinarian and Postdoctoral Research Fellow at the Julius Wolff Institute and Center for Musculoskeletal Research Charité – Universitätsmedizin Berlin
  • April 2006
  • 1999 – 2006
    Study of Veterinary Medicine, Freie Universität Berlin
  • Juni 1997
    Dissertation, Freie Universität Berlin
  • 1994 – 1997
    Doctoral Thesis in Molecularbiology, Institut für Genbiologische Forschung Berlin GmbH
  • 1993
    Diploma in Biology
  • 1987 – 1993
    Study of Biology, Universität Kaiserslautern and Universität Hamburg

Scientific Development

  • Seit Dez 2006 
    Veterinarian and Postdoctoral Fellow, Julius Wolff Institute, Charité
  • 1994 – 1997 
    Postdoctoral Fellow, Institut für Genbiologische Forschung Berlin GmbH

Functions / offices

Professional Affiliations

  • DGOU – Deutsche Gesellschaft für Orthopädie und Unfallchirurgie
  • European Calcified Tissue Society
  • International Society for Fracture Repai
  • ORS – Orthopaedic Research Society

Reviewer for

  • DFG- Deutsche ForschungsgemeinschaftJournal of Orthopeadic Researche
  • Cells & Materials Journal
  • Journal of Orthopaedic Trauma
  • Tissue Engineering: Parts A, B, & C
  • Veterinary and Comparative Orthopaedics and TraumatologyJournal of Biomechanics
  • Bone


  • BSRT Course Preclinical Studies I: Animal experiments in science
  • Practical Course on "Bone healing models and monitoring"
  • FELASA A and C course

Organizer of

  • Immune modulation as therapeutical strategy in bone regeneration; ORS workshop, New Orleans 2014
  • ISBR – International Symposium on Bone Regeneration, Berlin 2015
  • The good and the bad - interdependency of bone and immune cells: Possibilities for future treatments?; ORS workshop, Disney's Coronado Springs Resort 2016





Founded by the DFG (Project Number: 427826188)
Funding Period 2021-2024





Founded by the DFG (Project Nummer: 249509554)
Funding Period 2014-2022