Meta menu:

From here, you can access the Emergencies page, Contact Us page, Accessibility Settings, Language Selection, and Search page.

Open Menu

DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

You are here:

Subproject 5 - Principal Investgators

Dr. Sven Geißler

Subprojects 5 & 16

Prof. Dr. Carsten Perka

Subproject 5 & Central Service Project

Effects of implant-derived metal debris on bone formation and resorption

Geißler and Perka will investigate the effects of implant-derived metal exposure on bone remodelling and bone marrow composition. Implant-derived metal exposure represents a chronic pro-inflammatory model and disturbs the complex mutual regulation between multipotent lymphoid progenitor, adult immune and mesenchymal stromal cells. Bone homeostasis and regeneration are affected and long-lasting negative effects such as implant loosening and higher re-revision rates are observed in affected patients. Using patient material, the effect of metallic exposure on the pro-inflammatory environment in bone homeostasis will be characterised. A microfluidic 3D bone-on-a-chip system will be utilised to understand the effects of metal exposure on bone formation and how the individual immune profiles drives mechanisms and consequences of inflammation-associated bone loss.