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DFG Collaborative Research Centre 1444

This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.

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Subproject 15 - Principal Investgators

Effect of traumatic brain injury and traumatic spinal cord injury on energy distribution, alpha adrenergic signalling and bone regeneration

Surprisingly, old individuals with a traumatic brain injury see – if they survive – a substantial callus formation of their fractures. Similar effects are reported for some forms of traumatic spinal cord injuries. Overall, energy distribution, alpha-adrenergic signalling and bone regeneration seem to be coupled but the details of this coupling remain so far unknown. Tsitsilonis and Pumberger will analyse this paradoxical phenomenon. Previous data link this effect to an increased alpha-adrenergic signalling through an activated fat metabolism. In order to understand the strong neural component, the alpha-adrenergic component on bone formation during polytrauma injuries will be analysed. The neuroosteological aspect of this project is supported by metabolic and immunological aspects to enlarge the understanding of regenerative processes.