DFG Collaborative Research Centre 1444
This Collaborative Research Centre aims to unravel the basic mechanisms that differentiate between success and failure in regeneration of musculoskeletal tissue using bone healing as a role model.
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Subproject 1 - Principal Investgators
Understand and reshape the impact of an experienced adaptive immunity on fracture healing
Schmidt-Bleek and Volk aim to understand and reshape the impact of an experienced adaptive immunity on fracture healing. They will investigate the favourable and detrimental influence of specific immune cell subsets (effector CD8+ T cells, CD4+ T regulatory (Treg) cells, T helper 17 cells) and their cytokines and signalling cascades in an immune experienced, clinically relevant bone injury mouse model in order to understand their impact during bone regeneration. They aim to reshape the negative impact of an "experienced" pro-inflammatory adaptive immunity to enhance bone regeneration by local immunomodulation.