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Research Unit "Regeneration in aged"

The Research Unit 2165 Regeneration in Aged Individuals: Using Bone Healing as a Model System to Characterise Regeneration under Compromised Conditions aims to understand the basic mechanisms that impede the otherwise effective healing process along the two pathways of early immune response and restoration of mechanical competence through aging. 

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Project 5 - Principal Investgators

PD Dr. Katharina Schmidt-Bleek

CRC 1444 Deputy Scientific Coordinator & Implementation of 3R principles, Subprojects 1 & 12 | RU 2165 Subprojects 5 & 6

Katharina Schmidt-Bleek
Prof. Dr. Hans-Dieter Volk

CRC 1444 Deputy Spokesperson & Ombudsperson, Subprojects 1 & 2 | RU Subproject 5

Understand and reshape the impact of “aged” adaptive immunity and type 2 diabetes/obesity on fracture healing

Immune cells are essential for the onset of regeneration and for the successful completion of the process. A balanced adaptive immune response is a deciding factor in the regenerative cascade and immune modulatory strategies represent a new therapeutic approach to enhance healing. Even though the osteo-immunological research has progressed remarkably, the adaptive immunity is often not considered. Here, we will study the influence of the adaptive immunity in regenerative processes of elderly compromised patients (obese/ diabetic), develop a strategy to distract unfavourable immune cells from partaking in the early inflammatory reaction of healing, and analyse the influence of T cells on the collagen 1 deposition and osteogenic progenitor cell distribution during callus formation in bone healing situations. In close cooperation with other projects of the Research Unit the influence of adaptive immune cells on cellular senescence, adipogenic stem cell differentiation, and revascularisation will also be analyzed.

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Founded by the DFG (Project Number: 249509554)
Funding Period 2014-2022