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ISBR 2022 - Berlin 4-5 October 2022

The Internatioal Symposium on Bone Regeneration (ISBR) will be hosted within the framework of the DFG Collaborative Research Center 1444. We invite all researchers and clinicians interested on the topics of cell-matrix/cell-biomaterial interaction, osteo-immunology, angiogenesis and metabolism with a focus on musculoskeletal regeneration, while we particularly encourage young scientists to take the chance to meet, exchange and network.

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Keynote speakers

These keynote speakers have confirmed their participation. These experts will not only navigate us through their scientific discoveries but also through their career journey and the lessons learnt along the way. Young scientists will have the opportunity to share their findings and discuss their ideas.

Prof. Dr. Bent Brachvogel

Prof. Dr. Bent Brachvogel is the head of the experimental neonatologyat the University Hospital in Cologne. His research focusses on epigenetic and metabolic aspects of childrens health and the importance of the extracellular matrix for musculoskeletal development. The group of Prof. Bent Brachvogel aims to unravel the underlying molecular mechanism that lead to long-term health complications triggered by disruptions in early development.

Prof. Dr. Daniel Kelly

Dr. Daniel Kelly is the Professor of Tissue Engineering in Trinity College Dublin and one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre based in Trinity College Dublin. His research focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. Professor Kelly and his research group have demonstrated that adult stem cells isolated from synovial joints can be used to tissue engineer functional cartilage grafts, especially when combined with bioreactors to mechanically stimulate these cells. They have demonstrated that it is possible to engineer zonal tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. Realising this required undertaking a series of fundamental studies to understand how chondrogenesis, hypertrophy and endochondral ossification is regulated by altered levels of oxygen and mechanical cues. They have demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. More recently they have have utilised emerging biofabrication and bioprinting strategies to engineer structurally organised articular cartilage and stem cell laden constructs capable of supporting endochondral bone regeneration. They have also bioprinted implants containing spatiotemporally defined patterns of growth factors and demonstrated that printed constructs containing a gradient of VEGF, coupled with spatially defined BMP-2 localization and release kinetics, accelerated large bone defect healing with little heterotopic bone formation.

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Founded by the DFG (Project Number: 427826188)